At local, national and international levels, Tri-Delta provides financial contributions and volunteer man-hours to benefit the research and treatment of children with cancer. In November 1999, Tri-Delta expanded its philanthropic focus by forming a partnership with St. Jude's Children’s Research Hospital in Memphis, TN. In 2002 Tri-Delta agreed to a 4-year $1 million dollar commitment to fund the Patient Teen Room.  In May 2005 Tri Delta fulfilled the million dollar endowment for the Patient Teen Room! 

Tri Delta members have now agreed to a 5-7 year commitment of $7.5 million for the Patient Care Floor in the new Chili's Care Center at St. Jude's.